Towards solving the problem of star formation, from above Stars are born in dense molecular clouds in the turbulent interstellar medium. The impact of the global state of the galaxy versus the local small scale environment on this process is not yet fully understood. I will discuss the processes that shape the density and velocity structure of the interstellar medium, focusing on gravity and stellar feedback, leading to observed scaling relations of molecular clouds and large scale HI properties. On galactic scales, star formation is known to be globally inefficient, whereas individual star forming clouds show a puzzling diversity with a spread of efficiencies on the order of 4 orders of magnitude. I will show how high resolution models of galaxies can shed light on this problem. Finally, I will present new results on the formation of the faintest galaxies in the Universe, Ultra Faint Dwarfs (UFDs), and how their extremely inefficient mode of star formation can be understood.